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. 2022 Mar:171:103575.
doi: 10.1016/j.critrevonc.2021.103575. Epub 2021 Dec 28.

Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations

Stefano Tamburin  1 , Susanna B Park  2 , Angelo Schenone  3 , Elisa Mantovani  4 , Mehrnaz Hamedani  5 , Paola Alberti  6 , Vesile Yildiz-Kabak  7 , Ian R Kleckner  8 , Noah Kolb  9 , Miryam Mazzucchelli  10 , Brendan L McNeish  9 , Andreas A Argyriou  11 , Guido Cavaletti  6 , Ahmet Hoke  12 ; Toxic Neuropathy Consortium
Affiliations

Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations

Stefano Tamburin et al. Crit Rev Oncol Hematol. 2022 Mar.

Abstract

Pharmacological strategies for chemotherapy-induced peripheral neurotoxicity (CIPN) are very limited. We systematically reviewed data on rehabilitation, exercise, physical therapy, and other physical non-pharmacological interventions and offered evidence-based recommendations for the prevention and treatment of CIPN. A literature search using PubMed, Web of Science and CINAHL was conducted from database inception until May 31st, 2021. 2791 records were title-abstract screened, 71 papers were full-text screened, 41 studies were included, 21 on prevention and 20 on treatment of CIPN. Treatment type, cancer type, chemotherapy compounds were heterogeneous, sample size was small (median: N = 34) and intention-to-treat analysis was lacking in 26/41 reports. Because of the methodological issues of included studies, the reviewed evidence should be considered as preliminary. Exercise, endurance, strength, balance, and sensorimotor training have been studied in low-to-moderate quality studies, while the evidence for other treatments is preliminary/inconclusive. We offer recommendation for the design of future trials on CIPN.

Keywords: Chemotherapy-induced peripheral neurotoxicity (CIPN); Evidence-based medicine; Exercise; Physical therapy; Rehabilitation; Treatment.

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Conflict of interest statement

Declaration of Competing Interest None.

Figures

Fig. 1.
Fig. 1.
Assessment of the risk of bias according to the RoB 2.0 tool for the prevention (panel A) and therapeutic studies (panel B) included in the systematic review.
See this image and copyright information in PMC

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