Survival After Minimally Invasive Surgery in Older Women With Endometrial Carcinoma

Abstract

Background/aim: To analyze the impact of minimally invasive surgery for endometrial cancer on overall survival among age >65.

Patients and methods: We examined women who underwent hysterectomy from 2010 to 2015 from the U.S. National Cancer Data Base (NCDB). We evaluated the impact of surgical approach on survival.

Results: Of 243,601 endometrial cancer cases, 42,458 met the inclusion criteria. Laparoscopic approach was associated with improved survival by 14% (HR=0.86; 95%CI=0.80-0.92; p<0.001) and robotic approach was associated with improved survival by 12% (HR=0.88; 95%CI=0.83-0.93; p<0.0001), compared to the open approach. Similarly, the weighted adjusted 5-year overall survival was 73.1% (95%CI=72%-74.2%), 76.4% (95%CI=75.1-77.7%), and 75.5% (95%CI=74.7-76.4%) for open, laparoscopic, and robotic approaches, respectively (p<0.001).

Conclusion: Minimally invasive surgery improved overall survival in women over 65 years with endometrial cancer.

Keywords: Robotic surgical procedure; aged; endometrial neoplasm; laparoscopy; laparotomy; survival.