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Case Reports
. 2021 Dec 30;14(12):e246432.
doi: 10.1136/bcr-2021-246432.

Graves' disease following administration of second dose of SARS-CoV-2 vaccine

Timothy James Goblirsch  1 , Ambika E Paulson  2 , Gerti Tashko  3 , Asefa Jejaw Mekonnen  4
Affiliations
Case Reports

Graves' disease following administration of second dose of SARS-CoV-2 vaccine

Timothy James Goblirsch et al. BMJ Case Rep. .

Abstract

The SARS-CoV-2 vaccines have had an overwhelming success in curbing the COVID-19 global pandemic, accounting for countless lives saved. Adverse reactions are inevitable, given the vast scale of vaccination required to mitigate future surges of COVID-19. Hyperthyroid disorders have been reported as potential adverse reactions to SARS-CoV-2 vaccines in two patients with Graves' disease and a group of adults with subacute thyroiditis occurring in young women healthcare workers. We report a case of clinical Graves' disease in a woman with a previously stable multinodular goitre that occurred 14 days following her second dose of Pfizer-BioNTech SARS-CoV-2 vaccine.

Keywords: COVID-19; thyroid disease; thyrotoxicosis; unwanted effects/adverse reactions.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Thyroid function over time. TSH, thyroid stimulating hormone. TSI, thyroid stimulating immunoglobulin.
See this image and copyright information in PMC

References

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