Vaccine-induced immune thrombocytopenia and thrombosis: The decline in anti-platelet factor 4 antibodies is assay-dependent

Affiliations

¹ The Royal London Haemophilia Centre, Barts Health NHS Trust, London, UK.
² Institut für Immunologie und Transfusionsmedizin, Abteilung Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.
³ Department of Haematology, Barts Health NHS Trust, London, UK.
⁴ Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Sean Platton et al. Br J Haematol. 2022 May.

. 2022 May;197(4):428-430.

doi: 10.1111/bjh.18022. Epub 2021 Dec 30.

¹ The Royal London Haemophilia Centre, Barts Health NHS Trust, London, UK.
² Institut für Immunologie und Transfusionsmedizin, Abteilung Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany.
³ Department of Haematology, Barts Health NHS Trust, London, UK.
⁴ Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

No abstract available

Keywords: ELISA; platelet activation; thrombocytopenia; thrombosis; vaccines.

References

1. Pavord S, Hunt BJ, Horner D, Bewley S, Karpusheff J. Guideline Committee. Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance. BMJ. 2021;1(375):n2195. https://doi.org/10.1136/bmj.n2195
1. Pavord S, Scully M, Hunt BJ, Lester W, Bagot C, Craven B, et al. Clinical features of vaccine-induced immune thrombocytopenia and thrombosis. N Engl J Med. 2021;385(18):1680-9. https://doi.org/10.1056/NEJMoa2109908
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1. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination. N Engl J Med. 2021;384(22):2092-101. https://doi.org/10.1056/NEJMoa2104840
1. Platton S, Bartlett A, MacCallum P, Makris M, McDonald V, Singh D, Scully M, Pavord S. Evaluation of laboratory assays for anti-platelet factor 4 antibodies after ChAdOx1 nCOV-19 vaccination. J Thromb Haemost. 2021;19(8):2007-13. https://doi.org/10.1111/jth.15362