Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 May;22(5):1496-1497.
doi: 10.1111/ajt.16942. Epub 2022 Jan 17.

Mortality in solid organ transplant recipients with COVID-19: More than meets the eye

Umberto Maggiore  1 , Leonardo V Riella  2 , Jamil Azzi  3 , Paolo Cravedi  4
Affiliations
Comment

Mortality in solid organ transplant recipients with COVID-19: More than meets the eye

Umberto Maggiore et al. Am J Transplant. 2022 May.
No abstract available

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Comparison of COVID-19 associated mortality between SOT recipients and the general population. The plot shows how the analysis of hospital mortality may lead to misinterpretation of the comparison of COVID-19 related mortality between solid organ transplant (SOT) recipients and general population (non-SOT recipients). Hypothetical scenario in which the hospital mortality is 25% in both COVID-19 affected SOT recipients (n = 1000) and general population (n = 1000), but the hospitalization rate is four times higher in SOT recipients with respect to the general population, because SOT recipients are four times more likely to develop severe COVID-19 disease requiring hospitalization compared to the general population. After examining in-hospital mortality only, risk of death from COVID-19 would falsely appear equal in SOT recipients and general population (i.e., 25%) while deaths are in fact four times higher in SOT recipients (n = 100/1000) compared to the general population (n = 25/1000)
See this image and copyright information in PMC

Comment in

Comment on

  • Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic.
    Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach-Miller M, Blumberg EA, Multani A, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh PP, Hughes Kramer K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Derenge AC, van Duin D, Maximin A, Gilbert C, Goldman JD, Lease ED, Fisher CE, Limaye AP; UW COVID-19 SOT Study Team. Heldman MR, et al. Am J Transplant. 2022 Jan;22(1):279-288. doi: 10.1111/ajt.16840. Epub 2021 Oct 7. Am J Transplant. 2022. PMID: 34514710 Free PMC article.

References

    1. Heldman MR, Kates OS, Safa K, et al. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID-19 during the course of the pandemic. Am J Transplant. 2021. - PMC - PubMed
    1. Kalil AC, Florescu DF. Mortality in solid organ transplant recipients hospitalized for COVID-19. Am J Transplant. 2021. - PMC - PubMed
    1. Trapani S, Masiero L, Puoti F, et al. Incidence and outcome of SARS-CoV-2 infection on solid organ transplantation recipients: a nationwide population-based study. Am J Transplant. 2021;21(7):2509–2521. - PMC - PubMed
    1. Hadi YB, Naqvi SFZ, Kupec JT, Sofka S, Sarwari A. Outcomes of COVID-19 in solid organ transplant recipients: a propensity-matched analysis of a large research network. Transplant. 2021;105(6):1365–1371. - PMC - PubMed
    1. Colmenero J, Rodriguez-Peralvarez M, Salcedo M, et al. Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients. J Hepatol. 2021;74(1):148–155. - PMC - PubMed