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Editorial
. 2022 Mar 21;43(12):1265-1267.
doi: 10.1093/eurheartj/ehab873.

Cardiac desmosomal reserve: another piece of the exercise-induced arrhythmogenic cardiomyopathy puzzle?

Kristina H Haugaa  1   2   3 , Christine Rootwelt-Norberg  3   4
Affiliations
Editorial

Cardiac desmosomal reserve: another piece of the exercise-induced arrhythmogenic cardiomyopathy puzzle?

Kristina H Haugaa et al. Eur Heart J. .
No abstract available

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Figures

Graphical Abstract
Graphical Abstract
The study by Cerrone et al. showed that exercise reduced the cardiac desmosomal function. This was well tolerated in healthy murine hearts, which had a ‘desmosomal reserve’, but was catastrophic for mice with PKP2 deficiency. One can hypothesize that the desmosomal reserve may be part of the explanation of why some athletes without a known genetic predisposition develop ARVC. ARVC, arrhythmogenic right ventricular cardiomyopathy; PKP2, plakophillin-2.
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References

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