doi: 10.1016/0161-5890(87)90113-1.
The idiotypy of auto anti-allotype antibody induced in immunoglobulin allotype suppressed rabbits
- PMID: 3497334
- DOI: 10.1016/0161-5890(87)90113-1
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The idiotypy of auto anti-allotype antibody induced in immunoglobulin allotype suppressed rabbits
Mol Immunol.
1987 Jan.
Abstract
Rabbit anti-rabbit idiotype antibody was raised to both clonally heterogeneous and restricted auto anti-b6 antibodies induced in b6 allotype-suppressed (b6)/(b6) homozygous and b4/(b6) heterozygous rabbits. In every case the anti-idiotypic antibodies were specific only for the inducing antibody as shown by direct binding solid-phase RIA. Anti-idiotypes directed to the same antibody preparation had a similar but not identical specificity. It was demonstrated by IEF that the same idiotype specificity (spectrotype) was present throughout the anti-b6 response in individual rabbits.
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