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Comparative Study
. 1987;328(6129):395-9.
doi: 10.1038/328395a0.

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

A Sette, S Buus, S Colon, J A Smith, C Miles, H M Grey
Comparative Study

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

A Sette et al. Nature. 1987.

Abstract

A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

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