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Case Reports
. 2022 Jan-Feb;39(1):70-73.
doi: 10.4103/lungindia.lungindia_761_20.

Combined diffuse alveolar hemorrhage and venous thrombosis in a patient with granulomatosis with polyangiitis: Case report and systematic review of literature

Manu Madan  1 , Hariharan Iyer  1 , Pawan Tiwari  1 , Anant Mohan  1 , Karan Madan  1 , Vijay Hadda  1 , Saurabh Mittal  1 , Randeep Guleria  1
Affiliations
Case Reports

Combined diffuse alveolar hemorrhage and venous thrombosis in a patient with granulomatosis with polyangiitis: Case report and systematic review of literature

Manu Madan et al. Lung India. 2022 Jan-Feb.

Abstract

Antineutrophil cytoplasmic antibody-associated vasculitis has associations with both thrombosis and diffuse alveolar hemorrhage (DAH). Management of patients having coexistence of both thrombotic and hemorrhagic manifestations is challenging. Thrombotic conditions require anticoagulation, which can theoretically increase the risk of bleeding and thereby worsen DAH. In this review, we highlight the management of a patient of granulomatosis with polyangiitis with DAH who developed deep vein thrombosis. A systematic review of the literature was also performed summarizing and discussing the issues pertaining to the management of such patients.

Keywords: Antineutrophil cytoplasmic antibody-associated vasculitis; diffuse alveolar haemorrhage; granulomatosis with polyangiitis; thrombosis.

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Conflict of interest statement

None

Figures

Figure 1
Figure 1
Computed tomography chest showing bilateral consolidation and ground glassing with axial and basal predominance
Figure 2
Figure 2
Computed tomography chest showing resolution in the opacities
Figure 3
Figure 3
Computed tomography chest showing relapse with increase in areas of ground glass
Figure 4
Figure 4
Methodology of systematic review of literature regarding combined pulmonary hemorrhage and thrombosis in ANCA associated vasculitis
See this image and copyright information in PMC

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