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Review
. 2021 Dec 16:12:800693.
doi: 10.3389/fendo.2021.800693. eCollection 2021.

Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review

Ferdinando Fusco  1 , Nicola Longo  2 , Marco De Sio  3 , Davide Arcaniolo  3 , Giuseppe Celentano  2 , Marco Capece  2 , Roberto La Rocca  2 , Francesco Mangiapia  2 , Gianluigi Califano  2 , Simone Morra  2 , Carmine Turco  2 , Gianluca Spena  2 , Lorenzo Spirito  2 , Giovanni Maria Fusco  2 , Luigi Cirillo  2 , Luigi De Luca  2 , Luigi Napolitano  2 , Vincenzo Mirone  2 , Massimiliano Creta  2
Affiliations
Review

Impact of Circadian Desynchrony on Spermatogenesis: A Mini Review

Ferdinando Fusco et al. Front Endocrinol (Lausanne). .

Abstract

The purpose of this mini review is to provide data about pre-clinical and clinical evidence exploring the impact of circadian desynchrony on spermatogenesis. Several lines of evidence exist demonstrating that disruption of circadian rhythms may interfere with male fertility. Experimental knock-out or knock-down of clock genes, physiologically involved in the regulation of circadian rhythms, are associated with impairments of fertility pathways in both animal and human models. Moreover, disruption of circadian rhythms, due to reduction of sleep duration and/or alteration of its architecture can negatively interfere in humans with circulating levels of male sexual hormones as well as with semen parameters. Unfortunately, current evidence remains low due to study heterogeneity.

Keywords: circadian desynchrony; circadian rhythms; clock genes; fertility; spermatogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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