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. 2021 Dec 24:2021:3567447.
doi: 10.1155/2021/3567447. eCollection 2021.

The Effect and Mechanism of Exercise Training on Rats with Poststroke Depression Based on the Intestinal Flora

Jiaen Yang  1 , Guangjin Zhou  1 , Zixuan Ou  1 , Ning Jia  1 , Dong Wang  2
Affiliations

The Effect and Mechanism of Exercise Training on Rats with Poststroke Depression Based on the Intestinal Flora

Jiaen Yang et al. Comput Math Methods Med. .

Retraction in

Abstract

Depression of poststroke depression (PSD) is the most common neuropsychiatric complication after stroke. Patients with PSD had higher mortality, more cognitive disorder, lower quality of life, and higher suicidal tendency. The pathogenesis of PSD mainly involves neurotransmitter inflammatory factors, HPA and BDNF. Enteral dysfunction and intestinal flora disorders caused by stroke can participate in the pathogenesis of PSD through various ways, such as immune, endocrine, and nervous system. In this experiment, we used exercise training as an intervention means to explore the curative effect and possible mechanism by observing the changes of behavior, inflammatory factors, and intestinal flora in rats. The results show that the mechanism of exercise training to improve the depressive behavior of rats may be related to inhibiting the expression of proinflammatory factors and increasing the number of lactic acid bacteria in the intestine.

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Conflict of interest statement

There is no potential conflict of interest in our paper, and all authors have seen the manuscript and approved to submit to your journal. We confirm that the content of the manuscript has not been published or submitted for publication elsewhere.

Figures

Figure 1
Figure 1
Poststroke depression in different parts of different ages.
Figure 2
Figure 2
Behavioral experimental results of sham group.
Figure 3
Figure 3
PSD group behavioral experiment results.
Figure 4
Figure 4
Behavioral experiment results of PSD+ET group.
Figure 5
Figure 5
Protein expression results of intestinal tissue.
Figure 6
Figure 6
Protein expression results of brain tissue.
Figure 7
Figure 7
Expression of intestinal flora.
See this image and copyright information in PMC

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