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Review
. 2021 Nov 28;13(11):e19953.
doi: 10.7759/cureus.19953. eCollection 2021 Nov.

Inflammatory Markers, Metabolic Profile, and Psychoneurological Symptoms in Women with Breast Cancer: A Literature Review

Ahmad M Al-Bashaireh  1 , Omar Khraisat  1 , Eman K Alnazly  1 , Mohannad Aldiqs  1
Affiliations
Review

Inflammatory Markers, Metabolic Profile, and Psychoneurological Symptoms in Women with Breast Cancer: A Literature Review

Ahmad M Al-Bashaireh et al. Cureus. .

Abstract

Breast cancer is one of the most prevalent cancers in women. The improvement in breast cancer treatment has significantly increased the proportion of survival rate for women with breast cancer. Despite the advancement in breast cancer treatment, a great proportion of survivors suffer from co-occurring psychoneurological symptoms which impact their quality of life. The most frequently reported psychoneurological symptoms among women with breast cancer are depressive symptoms, anxiety, fatigue, sleep disturbances, and pain. These symptoms usually appear as a cluster. Inflammatory activation and serum metabolic alterations have been associated with the etiology of cancer and with various chronic neurocognitive disorders. However, to date, no studies considered the combined effects of inflammatory markers and metabolites in the development of psychoneurological symptoms in women with breast cancer especially those who were treated with chemotherapy. Further clarification of the relationships between the inflammatory markers, serum metabolic alterations, and psychoneurological symptoms in women with breast cancer should be pursued.

Keywords: breast cancer; inflammatory markers; metabolic profile; metabolites; psychoneurological symptoms.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Proposed theoretical framework.
CRP: C-reactive protein.
See this image and copyright information in PMC

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