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Comparative Study
. 1986;22 Suppl 2(Suppl 2):111S-116S.
doi: 10.1111/j.1365-2125.1986.tb02990.x.

Oxicams: relative safety and anti-injury effects in rats

M W Whitehouse
Comparative Study

Oxicams: relative safety and anti-injury effects in rats

M W Whitehouse. Br J Clin Pharmacol. 1986.

Abstract

1 Oxicams have certain distinctive properties, which distinguish them from other arylalkanoic (carboxylic) acids that show anti-inflammatory/analgesic/antipyretic activities. These include: (i) slow rates of metabolism (ii) lesser gastro-irritancy/ulcerogenicity (iii) preventing fever development (iv) some effect on the adaptive responses of the liver to severe inflammation or trauma that compromise normal hormone/xenobiotic metabolism (detoxification). 2 Isoxicam was notably less gastrotoxic than either piroxicam or tenoxicam, when given either orally or parenterally, at equipotent doses in rats.

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References

    1. Proc Soc Exp Biol Med. 1974 Jan;145(1):135-40 - PubMed
    1. Life Sci. 1977 Aug 1;21(3):371-7 - PubMed
    1. J Pharmacol Exp Ther. 1977 Oct;203(1):169-83 - PubMed
    1. J Pharm Pharmacol. 1980 Nov;32(11):795-6 - PubMed
    1. Br J Clin Pharmacol. 1986;22 Suppl 2:121S-124S - PubMed

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