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. 2021 Dec 15:9:797831.
doi: 10.3389/fbioe.2021.797831. eCollection 2021.

Biosensors for Point Mutation Detection

Hanlin Jiang  1 , Hui Xi  1 , Mario Juhas  2 , Yang Zhang  1
Affiliations

Biosensors for Point Mutation Detection

Hanlin Jiang et al. Front Bioeng Biotechnol. .
No abstract available

Keywords: SARS – CoV – 2; biosensor; cancer; detection; point mutation; virus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Composition, characteristics and application of biosensor. The figure summarizes the characteristics, recognition elements, applications and transducers of the biosensors which can be used for the detection of point mutations.
FIGURE 2
FIGURE 2
Schematic diagram of electrochemical sensor for mutation detection based on amplification effect of E. coli DNA ligase and AuNPs. The gap between the capture probe and AuNPs probe is closed by E. coli DNA ligase only in the sequence harboring mutation. The resulting differences in electrical signals can be used for the mutation identification.
FIGURE 3
FIGURE 3
Schematic diagram of SPR biosensor strategy for rapid and sensitive point mutation detection. Contrary to wild type sequence, sequences containing point mutation are not elongated and consequently hybridize with the capture probe on the sensor’s surface and produce measurable signal output.
See this image and copyright information in PMC

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