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. 2022 Jan:28:e00261.
doi: 10.1016/j.plabm.2021.e00261. Epub 2021 Dec 26.

SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system

Sridevi Devaraj  1   2 , Izmarie Poventud-Fuentes  1   2 , Matthew Girotto  1 , Jermaine Monroe  1 , Julie Boom  1   2 , George Delclos  1 , James Versalovic  1   2
Affiliations

SARSCoV-2 serostatus amongst vaccinated employees at a pediatric hospital system

Sridevi Devaraj et al. Pract Lab Med. 2022 Jan.

Abstract

To gain insights on the heterogeneity of immune responses to vaccination against SARS-CoV-2 and to identify factors that could make individuals vulnerable to infection due to lack of response to vaccination, our hospital started offering free voluntary post-antibody testing against the spike protein IgG for all fully vaccinated employees. Post-vaccination response against SARS-CoV-2 was assessed using the FDA-EUA approved VITROS anti-SARS-CoV-2 IgG immunometric assay specific to the spike protein. Out of a total of 3266 antibody tests performed in fully vaccinated Texas Children's, 99.4% had a positive antibody response to the spike protein. From the 21 employees (0.6%) that had a negative response, 66.7% reported taking immunosuppressive drugs and/or biologics. Our data shows that most of the employees tested at our institution mounted an immune response to the immunogen in the vaccine. Post-vaccination antibody testing against SARS-CoV-2 can provide useful information to guide decisions about future vaccine doses.

Keywords: Antibody; COVID; Employee; SARS-CoV-2; Serology; Vaccine.

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Conflict of interest statement

Authors have no disclosures/competing interests.

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