Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;94(5):1773-1776.
doi: 10.1002/jmv.27555. Epub 2022 Jan 8.

From Alpha to Omicron SARS-CoV-2 variants: What their evolutionary signatures can tell us?

Affiliations

From Alpha to Omicron SARS-CoV-2 variants: What their evolutionary signatures can tell us?

Robert Andreata-Santos et al. J Med Virol. 2022 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Three‐dimensional structural representation of the SARS‐CoV‐2 Spike protein exhibiting the mutations present in Omicron variant receptor‐binding motif (RBM). Blue and red spheres represent the RBM's substitutions. nAb, vaccine‐induced neutralizing‐antibody (silver); RBM, receptor‐binding motif (yellow) and RBD, receptor‐binding domain (green). The image was created with the Visual Molecular Dynamics (VMD) v.1.9.3 (http://www.ks.uiuc.edu/Research/vmd/)

Similar articles

Cited by

References

    1. Abdelrahman Z, Li M, Wang X. Comparative review of SARS‐CoV‐2, SARS‐CoV, MERS‐CoV, and influenza A respiratory viruses. Front Immunol. 2020;11:552909. 10.3389/fimmu.2020.552909 - DOI - PMC - PubMed
    1. Nunes DR, Braconi CT, Ludwig‐Begall LF, Arns CW, Duraes‐Carvalho R. Deep phylogenetic‐based clustering analysis uncovers new and shared mutations in SARS‐CoV‐2 variants as a result of directional and convergent evolution. medRxiv. 2021;12:434. 10.1101/2021.10.14.21264474 - DOI - PMC - PubMed
    1. Hoffmann M, Kleine‐Weber H, Schroeder S, et al. Molecular architecture of early dissemination and massive second wave of the SARS‐CoV‐2 virus in a major metropolitan area. mBio. 2020;11(6):e02707‐e02720. 10.1128/mBio.02707-20 - DOI - PMC - PubMed
    1. Yu F, Xiang R, Deng X, et al. Systemic effects of missense mutations on SARS‐CoV‐2 spike glycoprotein stability and receptor‐binding affinity. Brief Bioinform. 2021;22(2):1239‐1253. 10.1093/bib/bbaa233 - DOI - PMC - PubMed
    1. Smaoui MR, Yahyaoui H. Unraveling the stability landscape of mutations in the SARS‐CoV‐2 receptor‐binding domain. Sci Rep. 2021;11(1):9166. 10.1038/s41598-021-88696-5 - DOI - PMC - PubMed

Publication types

Supplementary concepts