Expression of taste signaling elements in jejunal tissue in subjects with obesity

Toshiaki Yasuo¹, G Craig Wood², Xin Chu², Peter Benotti², Christopher D Still², David D K Rolston², Robert F Margolskee³, Yuzo Ninomiya⁴, Peihua Jiang³

Affiliations

¹ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Department of Oral Physiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan. Electronic address: tyasuo@dent.asahi-u.ac.jp.
² Obesity Institute, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA.
³ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
⁴ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Graduate School of Dental Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan; Oral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061 Japan; Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.

PMID: 34979250
DOI: 10.1016/j.job.2021.12.006

Expression of taste signaling elements in jejunal tissue in subjects with obesity

Toshiaki Yasuo et al. J Oral Biosci. 2022 Mar.

. 2022 Mar;64(1):155-158.

doi: 10.1016/j.job.2021.12.006. Epub 2021 Dec 31.

Authors

Toshiaki Yasuo¹, G Craig Wood², Xin Chu², Peter Benotti², Christopher D Still², David D K Rolston², Robert F Margolskee³, Yuzo Ninomiya⁴, Peihua Jiang³

Affiliations

¹ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Department of Oral Physiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan. Electronic address: tyasuo@dent.asahi-u.ac.jp.
² Obesity Institute, Geisinger Medical Center, 100 North Academy Ave, Danville, PA 17822, USA.
³ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
⁴ Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Graduate School of Dental Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan; Oral Health Science Center, Tokyo Dental College, 2-9-18 Kandamisaki-cho, Chiyoda-ku, Tokyo 101-0061 Japan; Department of Oral Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558 Japan.

PMID: 34979250
DOI: 10.1016/j.job.2021.12.006

Abstract

Taste-signaling proteins, which are expressed throughout the digestive tract, are involved in regulating metabolism and immunity. This study aimed to determine if these genes are expressed and altered in jejunal tissues from patients with extreme obesity who received bariatric surgery. Reverse transcription polymerase chain reaction revealed that phospholipase C beta 2 and transient receptor potential channel M5 expression was downregulated in the jejunum of patients with a body mass index above 50, whereas gustducin expression remained unchanged. Our data suggest that taste-signaling dysregulation might contribute to obesity.

Keywords: Gustducin; Obesity; Phospholipase Cβ2 (PLCβ2); Taste; Transient receptor potential channel M5 (Trpm5).

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Conflicts of interest None of the authors declares a conflict of interest.

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Expression of taste signaling elements in jejunal tissue in subjects with obesity

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Expression of taste signaling elements in jejunal tissue in subjects with obesity

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Abstract

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