doi: 10.1016/0165-5728(87)90076-2.
Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection
- PMID: 3497946
- PMCID: PMC7134084
- DOI: 10.1016/0165-5728(87)90076-2
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Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection
J Neuroimmunol.
1987 Oct.
Abstract
Measles virus induced a marked increase in the expression of MHC-coded class I and class II antigens as detected by immunostaining during both fatal and non-fatal brain infections in rats. The distribution of these molecules in the brain was much more widespread than the occurrence of viral antigen suggesting a soluble factor for their induction. In 14-day-old rats with a non-fatal infection there was a marked infiltration of T lymphocytes of 'cytotoxic/suppressor' phenotype in the brain parenchyma, whereas T 'helper' cell phenotypes mainly were located perivascularly. In brains from newborn rats with a fatal infection no or only few lymphocytes were detected.
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