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. 2022 Jan 3;20(1):9.
doi: 10.1186/s12967-021-03217-2.

Diabetes, hypertension, and cardiovascular disease development

Fu-Shun Yen  1 , James Cheng-Chung Wei  2   3   4 , Lu-Ting Chiu  5   6 , Chih-Cheng Hsu  7   8   9 , Chii-Min Hwu  10   11
Affiliations

Diabetes, hypertension, and cardiovascular disease development

Fu-Shun Yen et al. J Transl Med. .

Abstract

Background: We aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

Methods: From January 1, 2000, to December 31, 2018, we identified 16,236 matched pairs of T2DM participants with and without HTN (T2DM cohorts), 53,509 pairs of HTN participants with and without T2DM (HTN cohorts), and 21,158 pairs of comorbid HTN and T2DM participants with T2DM history or HTN history (comorbid cohorts) from Taiwan's National Health Insurance Research Database. Cox proportional-hazard models were used to calculate the risk of cardiovascular disease.

Results: The mean follow-up time of this study was 6.75 years. Mean incident rates of coronary artery disease for T2DM cohorts, HTN cohorts, and comorbid cohorts were 16.80, 23.18, and 31.53 per 1000 person-years, respectively. The adjusted hazard ratios (HRs) (95% confidence intervals [95% CIs]) for incident coronary artery disease, stroke, and heart failure in T2DM participants with versus without HTN were 2.22 (2.07-2.37), 1.19 (1.16-1.23), and 0.92 (0.82-1.02), respectively; the adjusted HRs for HTN participants with versus without T2DM were 1.69 (1.55-1.84), 1.25 (1.21-1.30), and 0.98 (0.93-1.05), respectively; the adjusted HRs for comorbid T2DM and HTN participants with previous T2DM versus previous HTN were 2.78 (2.37-3.27), 1.20 (1.13-1.28), and 0.95 (0.88-1.03), respectively.

Conclusions: This nationwide cohort study demonstrated that both T2DM with subsequent HTN and HTN with subsequent diabetes were associated with higher cardiovascular disease risks.

Keywords: Coronary artery disease; Diabetes mellitus; Heart failure; Hypertension; Stroke.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Flowchart of study population selection
Fig. 2
Fig. 2
Comparison of the incidence rates of cardiovascular outcomes. a coronary artery disease (CAD); b stroke; c heart failure (HF). The numbers on the top of each bar graph indicate the incidence rates of cardiovascular disease. *P < .0001 indicates significantly different aHRs of outcomes between study and comparison groups
See this image and copyright information in PMC

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