Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 4;22(1):3.
doi: 10.1186/s12890-021-01741-x.

Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics

Min-Hye Kim #  1 , Hun Soo Chang #  2 , Jong-Uk Lee  3 , Ji-Su Shim  1 , Jong-Sook Park  4 , Young-Joo Cho  1 , Choon-Sik Park  3
Affiliations

Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics

Min-Hye Kim et al. BMC Pulm Med. .

Abstract

Background: Asthma exacerbation threatens patient's life. Several genetic studies have been conducted to determine the risk factors for asthma exacerbation, but this information is still lacking. We aimed to determine whether genetic variants of Oxidative Stress Responsive Kinase 1 (OXSR1), a gene with functions of salt transport, immune response, and oxidative stress, are associated with exacerbation of asthma.

Methods: Clinical data were obtained from 1454 asthmatics and single nucleotide polymorphisms (SNPs) of OXSR1 were genotyped. Genetic associations with annual exacerbation rate were analyzed depending on smoking status.

Results: Eleven SNPs were selected using Asian data in the International HapMap database. The common allele of rs1384006 C > T of OXSR1 showed a significantly higher annual exacerbation rate than the rare allele in non-smoking asthmatics (CC vs. CT vs. TT: 0.43 ± 0.04 vs. 0.28 ± 0.03 vs. 0.31 ± 0.09, P = 0.004, Pcorr = 0.039). The frequent exacerbators had a significantly higher frequency of the common allele of rs1384006 C > T than did the infrequent exacerbators (74.4% vs. 55.2%, P = 0.004, Pcorr = 0.038).

Conclusion: The common allele of rs1384006 C > T of OXSR1 was associated with the asthma exacerbation rate and a higher risk of being a frequent exacerbator, indicating that non-smoking asthmatics who carry common alleles may be vulnerable to asthma exacerbations.

Keywords: Asthma; Exacerbation; Non-smokers; Polymorphism.

PubMed Disclaimer

Conflict of interest statement

All listed authors declare that they have no relevant competing interests.

Figures

Fig. 1
Fig. 1
Map, SNP location and linkage disequilibrium (A) and haplotypes of each HapBlock (B) of the eleven SNPs in OXSR1 gene
Fig. 2
Fig. 2
Comparison of annual number of exacerbations according to the genotypes of rs1384006 on OXSR1
See this image and copyright information in PMC

References

    1. Herrera-Luis E, Hernandez-Pacheco N, Vijverberg SJ, Flores C, Pino-Yanes M. Role of genomics in asthma exacerbations. Curr Opin Pulm Med. 2019;25:101–112. - PubMed
    1. Park HW, Tantisira KG. Genetic signatures of asthma exacerbation. Allergy Asthma Immunol Res. 2017;9:191–199. - PMC - PubMed
    1. Kim M-A, Shin S-W, Park J-S, Uh S-T, Chang HS, Bae D-J, et al. Clinical characteristics of exacerbation-prone adult asthmatics identified by cluster analysis. Allergy Asthma Immunol Res. 2017;9:483–490. - PMC - PubMed
    1. Park SY, Jung HW, Lee JM, Shin B, Kim HJ, Kim MH, et al. Novel Trajectories for identifying asthma phenotypes: a longitudinal study in Korean Asthma Cohort, COREA. J Allergy Clin Immunol Pract. 2019;7:1850–7.e4. - PubMed
    1. Hunninghake GM, Soto-Quiros ME, Avila L, Su J, Murphy A, Demeo DL, et al. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007;120:84–90. - PubMed

Substances