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Randomized Controlled Trial
. 2022 Jan 4;26(1):9.
doi: 10.1186/s13054-021-03873-2.

Early, biomarker-guided steroid dosing in COVID-19 Pneumonia: a pilot randomized controlled trial

Yewande E Odeyemi  1 , Sarah J Chalmers  1 , Erin F Barreto  2 , Jacob C Jentzer  3 , Ognjen Gajic  4 , Hemang Yadav  1
Affiliations
Randomized Controlled Trial

Early, biomarker-guided steroid dosing in COVID-19 Pneumonia: a pilot randomized controlled trial

Yewande E Odeyemi et al. Crit Care. .

Abstract

ClinicalTrials.gov identifier (NCT number): NCT03852537 , Registered February 25, 2019.

Keywords: C-reactive protein; Coronavirus disease 2019; Corticosteroids.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Daily C-reactive protein distribution by arm. CRP: C-reactive Protein
See this image and copyright information in PMC

References

    1. COVID-19 Treatment Guidelines-NIH. (COVID-19 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. National Institutes of Health. Available at https://www.covid19treatmentguidelines.nih.gov/. Accessed [11/11/21]).
    1. Sinha P, Furfaro D, Cummings MJ, et al. Latent class analysis reveals COVID-19-related acute respiratory distress syndrome subgroups with differential responses to corticosteroids. Am J Respir Crit Care Med. 2021;204(11):1274–1285. doi: 10.1164/rccm.202105-1302OC. - DOI - PMC - PubMed
    1. Torres A, Sibila O, Ferrer M, et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 2015;313(7):677–686. doi: 10.1001/jama.2015.88. - DOI - PubMed
    1. Dexamethasone in Hospitalized Patients with Covid-19—Preliminary Report. New England Journal of Medicine 2020. 10.1056/NEJMoa2021436.

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