Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 4;14(1):1.
doi: 10.1186/s13098-021-00759-9.

Overweight/obesity in adolescents with type 1 diabetes belonging to an admixed population. A Brazilian multicenter study

Marilia Brito Gomes  1 , Deborah Conte  1 , Karla Rezende Guerra Drummond  2 , Felipe Mallmann  3 , André Araújo Pinheiro  4 , Franz Schubert Lopes Leal  5 , Paulo Henrique Morales  2 , Carlos Antonio Negrato  6
Affiliations

Overweight/obesity in adolescents with type 1 diabetes belonging to an admixed population. A Brazilian multicenter study

Marilia Brito Gomes et al. Diabetol Metab Syndr. .

Abstract

Background: To determine the prevalence of overweight/obesity and associated risk factors in Brazilian adolescents with type 1 diabetes (T1D) and its association with diabetic retinopathy (DR) and chronic kidney disease (CKD).

Methods: This study was performed in 14 Brazilian public clinics in ten cities, with 1,760 patients. 367 were adolescents (20.9%):184 females (50.1%), 176 (48.0%) Caucasians, aged 16.4 ± 1.9 years, age at diagnosis 8.9 ± 4.3 years, diabetes duration 8.1 ± 4.3 years, school attendance 10.9 ± 2.5 years and HbA1c 9.6 ± 2.4%.

Results: 95 (25.9%) patients presented overweight/obesity, mostly females. These patients were older, had longer diabetes duration, higher levels of total and LDL-cholesterol, higher prevalence of family history of hypertension, hypertension, undesirable levels of LDL-cholesterol, and metabolic syndrome compared to eutrophic patients. No difference was found regarding ethnicity, HbA1c, uric acid, laboratorial markers of non-alcoholic fatty liver disease (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase).

Conclusions: Almost one quarter of our patients presented overweight/obesity. These patients had higher prevalence of traditional risk factors for micro and macrovascular diabetes-related chronic complications such as diabetes duration, hypertension, high levels of LDL-cholesterol and metabolic syndrome. The majority of the patients with or without overweight/obesity presented inadequate glycemic control which is also an important risk factor for micro and macrovascular diabetes-related chronic complications. No association was found between overweight/obesity with diabetic CKD, DR and laboratorial markers of non-alcoholic fatty liver disease. The above-mentioned data point out that further prospective studies are urgently needed to establish the clinical prognosis of these young patients.

Keywords: Adolescents; Cardiovascular risk factors; Diabetes-related chronic complications; Glycemic control; Obesity; Overweight; Type 1 diabetes.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Prevalence of nutritional status of the studied population stratified according to BMI
See this image and copyright information in PMC

References

    1. Pozzilli P, Guglielmi C, Caprio S, Buzzetti R. Obesity, autoimmunity, and double diabetes in youth. Diabetes Care. 2011;34(Suppl2):S166–S170. doi: 10.2337/dc11-s213. - DOI - PMC - PubMed
    1. Libman IM, Pietropaolo M, Arslanian SA, LaPorte RE, Becker DJ. Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes. Diabetes Care. 2003;26(10):2871–2875. doi: 10.2337/diacare.26.10.2871. - DOI - PubMed
    1. Cleland SJ, Fisher BM, Colhoun HM, Sattar N, Petrie JR. Insulin resistance in type 1 diabetes: what is “double diabetes” and what are the risks? Diabetologia. 2013;56(7):1462–1470. doi: 10.1007/s00125-013-2904-2. - DOI - PMC - PubMed
    1. Giuffrida FM, Bulcão C, Cobas RA, Negrato CA, Gomes MB, Dib SA. Brazilian Type 1 Diabetes Study Group (BrazDiab1SG). Double-diabetes in a real-world sample of 2711 individuals: associated with insulin treatment or part of the heterogeneity of type 1 diabetes? Diabetol Metab Syndr. 2016;22(8):28. doi: 10.1186/s13098-016-0143-7. - DOI - PMC - PubMed
    1. Teupe B, Bergis K. Epidemiological evidence for “double diabetes”. Lancet. 1991;337(8737):361–362. doi: 10.1016/0140-6736(91)90988-2. - DOI - PubMed

LinkOut - more resources