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Review
. 2022 Jan 4;14(1):a041004.
doi: 10.1101/cshperspect.a041004.

A Matter of Life and Death

Douglas R Green  1
Affiliations
Review

A Matter of Life and Death

Douglas R Green. Cold Spring Harb Perspect Biol. .
No abstract available

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Figures

Figure 1.
Figure 1.
Apoptosis snapshots. (Images provided by Douglas R. Green.)
Figure 2.
Figure 2.
Autophagic cell death. (Left) The cell in the center is undergoing autophagic cell death. (Right) Another autophagic cell death. (Reprinted from Maclean et al. 2008. ©2008 with permission from the American Society for Clinical Investigation.)
Figure 3.
Figure 3.
Necrosis. (Images courtesy of Dr. Nigel Waterhouse, Mater Medical Research Institute, Brisbane, Australia.)
Figure 4.
Figure 4.
General caspase activation pathways.
Figure 5.
Figure 5.
Simplified scheme of the first part of the mitochondrial pathway. BCL-2 proteins control mitochondrial outer membrane permeabilization (MOMP), releasing proteins that include cytochrome c.
Figure 6.
Figure 6.
Simplified scheme of the mitochondrial pathway of apoptosis.
Figure 7.
Figure 7.
Simplified scheme of the death-receptor pathway of apoptosis, in which death receptors on the plasma membrane bind their ligands and, through several intermediaries, ultimately activate executioner caspases.
Figure 8.
Figure 8.
Simplified inflammasome, showing events leading to the twin events of activation of executioner caspases and the secretion of inflammatory mediators.
See this image and copyright information in PMC

References

    1. Green DR. 2022. Inflammasomes and other caspase-activation platforms. Cold Spring Harb Perspect Biol 10.1101/cshperspect.a041061 - DOI - PMC - PubMed

FIGURE CREDIT

    1. Maclean KH, Dorsey FC, Cleveland JL, Kastan MB. 2008. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118: 79–88. 10.1172/JCI33700 - DOI - PMC - PubMed

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