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Comment
. 2022 Jan 4;7(1):5.
doi: 10.1038/s41392-021-00864-1.

Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution

Yier Lu  1   2 , Chenyang Ye  3   4 , Ying Yuan  5   6
Affiliations
Comment

Phenotypic characteristics and T cell receptor properties in melanoma: deciphering the correlation at single-cell resolution

Yier Lu et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Model of the relationship between cellular phenotype and TCR properties. a Measuring upon co-culture of multicolor-labeled CD8+ T cells against pdMel-CLs and against EBV-LCLs with peptides from NeoAgs, MAAs or viral antigens. CD8+ TILs with exhausted states (including TTE, TAct and TPE) were enriched in antitumour specificities, whereas CD8+ TILs with memory states (including TEM and TM) predominantly recognize EBV-LCLs. b The concentration level of cognate antigens influences the avidity of tumor specific TCRs. The figure was generated on Biorender.com. Abbreviations: TTE terminally exhausted T cell, TAct acutely activated T cell, TPE precursor exhausted T cell, TEM effector memory T cell, TM memory T cell
See this image and copyright information in PMC

Comment on

  • Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.
    Oliveira G, Stromhaug K, Klaeger S, Kula T, Frederick DT, Le PM, Forman J, Huang T, Li S, Zhang W, Xu Q, Cieri N, Clauser KR, Shukla SA, Neuberg D, Justesen S, MacBeath G, Carr SA, Fritsch EF, Hacohen N, Sade-Feldman M, Livak KJ, Boland GM, Ott PA, Keskin DB, Wu CJ. Oliveira G, et al. Nature. 2021 Aug;596(7870):119-125. doi: 10.1038/s41586-021-03704-y. Epub 2021 Jul 21. Nature. 2021. PMID: 34290406 Free PMC article.

References

    1. Oliveira G, et al. Phenotype, specificity and avidity of antitumour CD8(+) T cells in melanoma. Nature. 2021;596:119–125. doi: 10.1038/s41586-021-03704-y. - DOI - PMC - PubMed
    1. Simoni Y, et al. Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates. Nature. 2018;557:575–579. doi: 10.1038/s41586-018-0130-2. - DOI - PubMed
    1. Li H, et al. Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma. Cell. 2019;176:775–789 e718. doi: 10.1016/j.cell.2018.11.043. - DOI - PMC - PubMed
    1. Thommen DS, et al. A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade. Nat. Med. 2018;24:994–1004. doi: 10.1038/s41591-018-0057-z. - DOI - PMC - PubMed
    1. Park SL, et al. Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin. Nature. 2018;565:366–371. doi: 10.1038/s41586-018-0812-9. - DOI - PubMed

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