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Multicenter Study
. 2022 Jun;50(3):747-752.
doi: 10.1007/s15010-021-01751-1. Epub 2022 Jan 4.

COVID-19: vaccination vs. hospitalization

Oguz Uzun  1   2 , Tekin Akpolat  3 , Ayhan Varol  4 , Sema Turan  5 , Serife Gokbulut Bektas  5 , Pelin Duru Cetinkaya  6 , Mazlum Dursun  7 , Nurten Bakan  8 , Burcu Baran Ketencioglu  9 , Murat Bayrak  4 , Serap Argun Baris  10 , Rahmet Guner  11 , Ozgur Gunal  12 , Serkan Nural  13 , Pelin Pinar Deniz  14 , Oya Baydar Toprak  15 , Gulcihan Ozkan  16 , Ayça Gumus  4 , Ferhan Kerget  17 , Merve Ercelik  18 , Ozlem Ataoglu  19 , Aycan Yuksel  20 , Gungor Ates  21 , Oya Eren Kutsoylu  22 , Neslihan Kose  23 , Deniz Kizilirmak  24 , Serdar Keskin  7 , Okkes Gultekin  25 , Nilüfer Coskun  8 , Emine Serap Yilmaz  26 , Selen Uslu  26 , İlknur Basyigit  10 , Begüm Ergan  27 , Figen Deveci  28 , Mehmet Nuri Yakar  29 , Cigdem Zuhur  30 , Gulseren Sagcan  31 , Zeynep Ture Yuce  32 , Mutlu Kuluozturk  28 , Mehmet Emin Sezgin  7 , Esma Nur Aktepe Sezgin  7 , Yavuz Havlucu  24 , Caglar Cuhadaroglu  31 , Oguz Kilinc  33 , Hasim Boyaci  10 , Hayriye Altunay  7 , Mehmet Akti  7 , Zehra Bastepe Dursun  34 , Ayse Kaya Kalem  11 , Sinem Akkaya Isik  35 , Levent Akyildiz  36 , Nilüfer Aykac  37 , Mehmet Selim Almaz  36 , Nurdan Kokturk  38 , Oya Itil  39
Affiliations
Multicenter Study

COVID-19: vaccination vs. hospitalization

Oguz Uzun et al. Infection. 2022 Jun.

Abstract

Objective: Vaccination is the most efficient way to control the coronavirus disease 2019 (COVID-19) pandemic, but vaccination rates remain below the target level in most countries. This multicenter study aimed to evaluate the vaccination status of hospitalized patients and compare two different booster vaccine protocols.

Setting: Inoculation in Turkey began in mid-January 2021. Sinovac was the only available vaccine until April 2021, when BioNTech was added. At the beginning of July 2021, the government offered a third booster dose to healthcare workers and people aged > 50 years who had received the two doses of Sinovac. Of the participants who received a booster, most chose BioNTech as the third dose.

Methods: We collected data from 25 hospitals in 16 cities. Patients hospitalized between August 1 and 10, 2021, were included and categorized into eight groups according to their vaccination status.

Results: We identified 1401 patients, of which 529 (37.7%) were admitted to intensive care units. Nearly half (47.8%) of the patients were not vaccinated, and those with two doses of Sinovac formed the second largest group (32.9%). Hospitalizations were lower in the group which received 2 doses of Sinovac and a booster dose of BioNTech than in the group which received 3 doses of Sinovac.

Conclusion: Effective vaccinations decreased COVID-19-related hospitalizations. The efficacy after two doses of Sinovac may decrease over time; however, it may be enhanced by adding a booster dose. Moreover, unvaccinated patients may be persuaded to undergo vaccination.

Keywords: BioNTech; COVID-19 pandemic; COVID-19 vaccine; SinoVac.

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Conflict of interest statement

None of the authors have conflict of interest to declare.

Comment in

  • COVID-19: booster(s) vs. hospitalization and Intensive Care Unit admission.
    Baydar Toprak O, Akpolat T, Uzun O, Pınar Deniz P, Kokturk N, Varol A, Guzel E, Ercelik M, Gultekin O, Guner R, Turan S, Gökbulut Bektaş Ş, Coskun N, Bakan N, Nuri Yakar M, Eren Kutsoylu O, Ergan B, Argun Barış S, Başyiğit I, Boyacı H, Çetinkaya F, Çolak H, Aykac N, Baran Ketencioğlu B, Türe Yüce Z, Akkaya Isık S, Serap Yılmaz E, Karaoğlanoğlu S, Berik Safci S, Ozkan G, Kose N, Kizilirmak D, Havlucu Y, Nural S, Kerget F, Sunal Ö, Yuksel A, Bestepe Dursun Z, Deveci F, Kuluozturk M, Ataoglu O, Dursun M, Keskin S, Emin Sezgin M, Aktepe Sezgin EN, Eser F, Akyildiz L, Selim Almaz M, Kayaaslan B, Hasanoğlu I, Bayrak M, Gümüş A, Sağcan G, Cuhadaroglu C, Kucuk H, Onyilmaz T, Mete B, Kilinc O, Oya Itil B. Baydar Toprak O, et al. Eur Rev Med Pharmacol Sci. 2023 Mar;27(5):2132-2142. doi: 10.26355/eurrev_202303_31586. Eur Rev Med Pharmacol Sci. 2023. PMID: 36930513

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