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. 2022 May;16(3):371-375.
doi: 10.1111/irv.12931. Epub 2022 Jan 4.

Validation of International Classification of Diseases criteria to identify severe influenza hospitalizations

Brittney M Snyder  1 , Megan F Patterson  1 , Tebeb Gebretsadik  2 , Pingsheng Wu  1   2 , Tan Ding  2 , Rees L Lee  3 , Kathryn M Edwards  4 , Lindsay A Somerville  5 , Thomas J Braciale  6 , Justin R Ortiz  7 , Tina V Hartert  1   4
Affiliations

Validation of International Classification of Diseases criteria to identify severe influenza hospitalizations

Brittney M Snyder et al. Influenza Other Respir Viruses. 2022 May.

Abstract

In this cohort study of hospitalized patients with linked medical record data, we developed International Classification of Diseases (ICD) criteria that accurately identified laboratory-confirmed, severe influenza hospitalizations (positive predictive value [PPV] 80%, 95% confidence interval [CI] 71-87%), which we validated through medical record documentation. These criteria identify patients with clinically important influenza illness outcomes to inform evaluation of preventive and therapeutic interventions and public health policy recommendations.

Keywords: International Classification of Diseases; hospitalization; medical record extraction; severe influenza; validation.

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Conflict of interest statement

The authors have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of International Classification of Diseases (ICD) criteria validation with medical record documentation. The green box represents patients identified by our severe influenza hospitalization ICD criteria. The purple boxes represent patients with laboratory‐confirmed influenza and laboratory‐confirmed, severe influenza identified by medical record review. Descriptions of those without laboratory‐confirmed influenza or laboratory‐confirmed, severe influenza identified by medical record review are listed in the grey boxes. (CF, cystic fibrosis). This figure was created with BioRender.com
FIGURE 2
FIGURE 2
International Classification of Diseases (ICD) criteria accurately identified laboratory‐confirmed, severe influenza hospitalizations at Vanderbilt University Medical Center during influenza seasons, 1995–2017. (A) Positive influenza test type among patients with laboratory‐confirmed influenza identified by medical record review (n = 85/100 severe influenza hospitalizations identified by ICD criteria). (B) Type of severe influenza outcomes among patients with laboratory‐confirmed, severe influenza identified by medical record review (n = 80/100 severe influenza hospitalizations identified by ICD criteria). (PCR, polymerase chain reaction). *Confirmed influenza cases had documented influenza confirmation only at an outside hospital with an unknown test type
See this image and copyright information in PMC

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