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. 2022 Jan 19;20(3):565-569.
doi: 10.1039/d1ob02236a.

Thioether-directed Rh(III)-catalyzed peri-selective acyloxylation of arenes

Hui Xie  1 , Jia-Lin Song  1 , Chun-Yong Jiang  2 , Yan-Xia Huang  1 , Jun-Yi Zeng  1 , Xu-Ge Liu  3 , Shang-Shi Zhang  1 , Fan Yang  1
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Thioether-directed Rh(III)-catalyzed peri-selective acyloxylation of arenes

Hui Xie et al. Org Biomol Chem. .

Abstract

A thioether directed acyloxylation of arenes has been realized via Cp*Rh(III)-catalyzed C-H activation and subsequent coupling with carboxylic acids. This new method showed high functional group compatibility and broad substrate scope. Primary mechanistic studies have been conducted and a tentative reaction mechanism was proposed. It represents the first example of a thioether-directed Cp*Rh(III)-catalyzed C(sp2)-H acyloxylation reaction.

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