Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E2 synthase-1
- PMID: 34985304
- PMCID: PMC8905551
- DOI: 10.4155/fmc-2021-0317
Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E2 synthase-1
Keywords: COX-2 inhibitor; anti-inflammation; inhibitor; mPGES-1; microsomal prostaglandin E2 synthase-1.
Conflict of interest statement
The authors are funded by the following: American Heart Association (10GRNT4470042, 14GRNT20380687), US Department of Health and Human Services, and National Institutes of Health (HL56712, HL79389). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.
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References
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- Luz JG, Antonysamy S, Kuklish SL et al. Crystal structures of mPGES-1 inhibitor complexes form a basis for the rational design of potent analgesic and anti-inflammatory therapeutics. J. Med. Chem. 58(11), 4727–4737 (2015). - PubMed
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