Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Mar;14(6):385-388.
doi: 10.4155/fmc-2021-0317. Epub 2022 Jan 5.

Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E2 synthase-1

Affiliations
Editorial

Latest progress in the development of cyclooxygenase-2 pathway inhibitors targeting microsomal prostaglandin E2 synthase-1

Krista LaBorde et al. Future Med Chem. 2022 Mar.
No abstract available

Keywords: COX-2 inhibitor; anti-inflammation; inhibitor; mPGES-1; microsomal prostaglandin E2 synthase-1.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure

The authors are funded by the following: American Heart Association (10GRNT4470042, 14GRNT20380687), US Department of Health and Human Services, and National Institutes of Health (HL56712, HL79389). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Similar articles

Cited by

References

    1. Finetti F, Terzuoli E, Bocci E et al. Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis. PLoS ONE 7(7), e40576 (2012). - PMC - PubMed
    1. Chang HH, Meuillet EJ. Identification and development of mPGES-1 inhibitors: where we are at? Future Med. Chem. 3(15), 1909–1934 (2011). - PMC - PubMed
    1. Ding K, Zhou Z, Hou S et al. Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs. Sci. Rep. 8(1), 5205 (2018). - PMC - PubMed
    1. Luz JG, Antonysamy S, Kuklish SL et al. Crystal structures of mPGES-1 inhibitor complexes form a basis for the rational design of potent analgesic and anti-inflammatory therapeutics. J. Med. Chem. 58(11), 4727–4737 (2015). - PubMed
    1. Sjogren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S. Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. Proc. Natl Acad. Sci. USA 110(10), 3806–3811 (2013). - PMC - PubMed

Publication types

MeSH terms