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. 2022 Feb 1;158(2):212-214.
doi: 10.1001/jamadermatol.2021.5294.

Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis

Franziska Schauer  1 , Shoko Mai  2 , Silke C Hofmann  1   3 , Yosuke Mai  2 , Kentaro Izumi  2 , Johannes Steffen Kern  1   4 , Dimitra Kiritsi  1
Affiliations

Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis

Franziska Schauer et al. JAMA Dermatol. .

Abstract

This case series characterizes immune profiles of pregnant people with pemphigoid gestationis.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Schauer reported funding from the Berta-Ottenstein-Programme for Advanced Clinician Scientists, Faculty of Medicine, University of Freiburg. Dr Kiritsi reported funding from the Berta-Ottenstein-Programme for Advanced Clinician Scientists, Faculty of Medicine, University of Freiburg, the German Research Foundation, and the Fritz Thyssen Foundation. No other disclosures were reported.

Figures

Figure.
Figure.. Immunological Analyses in the Present Study Cohort of Patients With Pemphigoid Gestationis
Direct immunofluorescence results of 6 patients with linear C4d (A) and IgG1 (B) depositions along the basement membrane zone (BMZ). As positive controls, skin samples of patients with classical bullous pemphigoid were used. Arrows highlight the positive staining along the BMZ. C, Immunoblot results from the patients in our cohort. On the right side, a schematic diagram of the epitopes of BP180, as identified per immunoblot, is shown. NA indicates not applicable, NC, negative control; PC, positive control.
See this image and copyright information in PMC

References

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