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. 2021 Dec;15(6):2804-2812.
doi: 10.1007/s11682-021-00603-8. Epub 2022 Jan 5.

Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)

Marianna La Rocca  1 , Giuseppe Barisano  2 , Alexis Bennett  2 , Rachael Garner  2 , Jerome Engel  3 , Emily J Gilmore  4 , David L McArthur  3 , Eric Rosenthal  5 , James Stanis  2 , Paul Vespa  3 , Frederick Willyerd  6 , Lara L Zimmermann  7 , Arthur W Toga  2 , Dominique Duncan  2 ; EpiBioS4Rx Study Group
Affiliations

Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)

Marianna La Rocca et al. Brain Imaging Behav. 2021 Dec.

Abstract

Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We describe lesion identification and segmentation of hemorrhagic contusions by early posttraumatic magnetic resonance imaging (MRI). We describe the preliminary methods of manual lesion segmentation in an initial cohort of 32 TBI patients from the EpiBioS4Rx cohort and the preliminary association of hemorrhagic contusion and edema location and volume to seizure incidence.

Keywords: Lesion segmentation; Lesion volume analysis; Posttraumatic late seizures; Traumatic brain injury.

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Conflict of interest statement

Conflicts of Interest/ Competing interests

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

We have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Boxplots of the distributions of the total lesion volumes, contusion volumes, and edema volumes for the late seizure-affected subjects (salmon boxplot) and the seizure-free subjects (cyan boxplot). Seizure-affected group includes TBI subjects who had at least a single seizure one week after the TBI.
Figure 2
Figure 2
Histograms indicating occurrence percentage of the anatomical brain regions that are affected by lesions in most TBI subjects (occurrence greater than the 98th quantile of the occurrence distribution). Region occurrences are reported for two clinical groups: late seizure-affected subjects (blue histogram and seizure-free subjects (gold histogram). L and R indicate left and right, WM and GM indicate white matter and gray matter, BA indicate Brodmann area, Temp, Front, Sup, Lat and Ant stand for temporal, frontal, superior, lateral and anterior, respectively.
Figure 3
Figure 3
Axial, coronal, and sagittal view of the brain areas in which the highest percentage of TBI subjects with late seizures (top row) and without seizures (bottom row) have lesions. Each colormap represents the percentage of subjects in each TBI group who have lesions in that area according to the color code reported in the figure. This figure was obtained with BrainNet Viewer (Xia et al., 2013).
See this image and copyright information in PMC

References

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MeSH terms