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Review
. 2022 Feb 20;40(6):635-641.
doi: 10.1200/JCO.21.01719. Epub 2022 Jan 5.

Practical Management of Oligometastatic Non-Small-Cell Lung Cancer

Katie Jasper  1   2 , Brendon Stiles  3 , Fiona McDonald  4 , David A Palma  1
Affiliations
Review

Practical Management of Oligometastatic Non-Small-Cell Lung Cancer

Katie Jasper et al. J Clin Oncol. .

Abstract

Local ablative therapies, including surgery or stereotactic radiotherapy (SABR), are becoming an integral component in the treatment of oligometastatic disease in non-small-cell lung cancer. In this review, we summarize recent randomized evidence supporting progression-free survival and overall survival benefits of local ablation in these patients, as well as upcoming phase III data which should help us better understand the ideal treatment conditions and provide more insight into the oligometastatic state. Since practical management of oligometastatic disease in non-small-cell lung cancer can be challenging, we discuss a modern framework to identify patient, tumor, and treatment characteristics that can best guide management.

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Conflict of interest statement

Brendon StilesEmployment: PPD, Xalud TherapeuticsLeadership: PPD, Verrica PharmaceuticalsStock and Other Ownership Interests: Pfizer, PPD, Xalud TherapeuticsHonoraria: AstraZeneca, Pfizer, Bristol Myers Squibb, GenentechConsulting or Advisory Role: AstraZeneca, Pfizer, Gala TherapeuticsOther Relationship: Lung Cancer Research FoundationOpen Payments Link: https://openpaymentsdata.cms.gov/physician/227226 Fiona McDonaldSpeakers' Bureau: AstraZeneca David A. PalmaThis author is a member of the Journal of Clinical Oncology Editorial Board. Journal policy recused the author from having any role in the peer review of this manuscript.Employment: London Health Sciences Centre (LHSC)Patents, Royalties, Other Intellectual Property: US Patent: A Method for Analyzing a Three-Dimensional Computed Tomography Image, United States Patent Application No. 61/896349 (not licensed, no commercial or financial impact)No other potential conflicts of interest were reported.

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