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Comment
. 2022 Jan 4;34(1):5-7.
doi: 10.1016/j.cmet.2021.12.008.

Targeting p21 for diabetes: Another choice of senotherapy

Hiroshi Kondoh  1 , Eiji Hara  2
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Comment

Targeting p21 for diabetes: Another choice of senotherapy

Hiroshi Kondoh et al. Cell Metab. .
Free article

Abstract

Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population, occur in the adipose tissue during obesity. Targeting them genetically or pharmacologically attenuates insulin resistance, suggesting a possible therapeutic approach to treat the metabolic complications of obesity.

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