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Comment
. 2022 Jan 4;34(1):7-9.
doi: 10.1016/j.cmet.2021.12.015.

Palmitic acid: Enabling the tumor's nerves

H Furkan Alkan  1 , Patricia Altea-Manzano  1 , Sarah-Maria Fendt  2
Affiliations
Free article
Comment

Palmitic acid: Enabling the tumor's nerves

H Furkan Alkan et al. Cell Metab. .
Free article

Abstract

Diet can influence tumor aggressiveness. Recently in Nature, a study by Pascual et al. provided evidence that dietary palmitic acid induces an epigenetic memory by modulating particular histone methylation marks in cancer cells. This allows cancer cells to activate extracellular matrix secretion from Schwann cells of the tumor microenvironment, which ultimately potentiates metastasis initiation.

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Conflict of interest statement

Declaration of interests S.-M.F. acknowledges funding from Bayer, Merck, and BlackBelt Therapeutic; has consulted for Fund+; and is an advisory board member for Alesta Therapeutics, Cell Metabolism, Molecular Cell, Cell Reports, Metabolic Engineering, Life Science Alliance, Cancer Reports, and Molecular Metabolism. All other authors have no competing interests.

Comment on

  • Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
    Pascual G, Domínguez D, Elosúa-Bayes M, Beckedorff F, Laudanna C, Bigas C, Douillet D, Greco C, Symeonidi A, Hernández I, Gil SR, Prats N, Bescós C, Shiekhattar R, Amit M, Heyn H, Shilatifard A, Benitah SA. Pascual G, et al. Nature. 2021 Nov;599(7885):485-490. doi: 10.1038/s41586-021-04075-0. Epub 2021 Nov 10. Nature. 2021. PMID: 34759321

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