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Meta-Analysis
. 2022;40(6):745-753.
doi: 10.1159/000521768. Epub 2022 Jan 5.

Increased Risk of Liver-Related Outcomes in Chronic Hepatitis B Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis

Khin Naing Thin  1   2 , Andrew Tran  1   3 , Jie Li  4   5 , Eunice Yewon Lee  1 , Hongli Yang  6 , Fajuan Rui  6   7 , Chuanli Liu  6   7 , Christopher D Stave  8 , Ramsey C Cheung  1   9 , Mindie H Nguyen  1   10
Affiliations
Meta-Analysis

Increased Risk of Liver-Related Outcomes in Chronic Hepatitis B Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis

Khin Naing Thin et al. Dig Dis. 2022.

Abstract

Introduction: Chronic hepatitis B (CHB) patients with metabolic syndrome (MetS) may present increased risk of liver-related outcomes (LROs), but prior studies were limited by small sample size and/or conflicting results. Using a systematic review and meta-analytic approach, we aimed to determine the association between MetS and LROs in CHB.

Methods: Two researchers independently screened studies from the PubMed, Embase, Web of Science, and Cochrane Library databases from inception to January 21, 2020, and extracted the data. Estimates were pooled using a random-effects model.

Results: We screened 2,228 articles and included 10 eligible studies (18,360 CHB patients, 2,557 with MetS). MetS was significantly associated with LROs overall (odds ratio = 2.45, 95% confidence interval = 1.39-4.32) but not the individual LRO components but subgroup analyses were limited by small study numbers.

Discussion/conclusion: MetS is associated with almost 3-folds higher risk of LROs in CHB and should be considered in management decisions. However, additional studies are needed.

Keywords: Diabetes; Hepatocellular carcinoma; Liver fibrosis; Mortality; Prognosis.

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Conflict of interest statement

Mindie Nguyen has served as a consultant or in advisory board for Spring Bank, Novartis, Gilead, Intercept, Exact Sciences, Laboratory of Advanced Medicine, Eisai, and Bayer and has received grant/research support from Gilead, Pfizer, Enanta, Vir, National Cancer Institute, B. K. Kee Foundation, and Glycotest. All others: none to declare.

Figures

Fig. 1
Fig. 1
Systematic literature search and screening for outcomes of CHB in patients with MetS.
Fig. 2
Fig. 2
Forest plot for association of HBV patients with MetS and LROs.
Fig. 3
Fig. 3
Forest plot for subgroup analysis.
See this image and copyright information in PMC

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