Schizophrenia: genetic insights with clinical potential
- PMID: 34987233
- DOI: 10.1038/s41582-021-00613-6
Schizophrenia: genetic insights with clinical potential
Comment on
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Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants.Mol Psychiatry. 2022 Mar;27(3):1448-1454. doi: 10.1038/s41380-021-01387-5. Epub 2021 Nov 19. Mol Psychiatry. 2022. PMID: 34799693 Free PMC article.
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The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders.Mol Psychiatry. 2022 Mar;27(3):1435-1447. doi: 10.1038/s41380-021-01383-9. Epub 2021 Nov 19. Mol Psychiatry. 2022. PMID: 34799694
References
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- Charlson, F. J. et al. Global epidemiology and burden of schizophrenia: findings from the Global Burden of Disease Study 2016. Schizophr. Bull. 44, 1195–1203 (2018). - DOI
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- Smeland, O. B., Frei, O., Dale, A. M. & Andreassen, O. A. The polygenic architecture of schizophrenia — rethinking pathogenesis and nosology. Nat. Rev. Neurol. 16, 366–379 (2020). - DOI
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- The Schizophrenia Working Group of the Psychiatric Genomics Consortium. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Preprint at https://www.medrxiv.org/content/10.1101/2020.09.12.20192922v1 (2020).
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- Singh, T., Neale, B. M. & Daly, M. J. Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia. Preprint at https://www.medrxiv.org/content/10.1101/2020.09.18.20192815v1 (2020).
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- Smeland, O. B. & Andreassen, O. A. Polygenic risk scores in psychiatry – large potential but still limited clinical utility. Eur. Neuropsychopharmacol. 51, 68–70 (2021). - DOI
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