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Case Reports
. 2021 Sep 4;7(12):806-811.
doi: 10.1016/j.hrcr.2021.08.013. eCollection 2021 Dec.

Incessant atrial and ventricular tachycardias associated with an SCN5A mutation

John Papagiannis  1 , Tao Yang  2 , Andrew M Glazer  2 , Svjetlana Tisma-Dupanovic  3 , Dimosthenis Avramidis  1 , Prince J Kannankeril  2 , Sami Viskin  4 , Edward P Walsh  5 , Dan M Roden  2
Affiliations
Case Reports

Incessant atrial and ventricular tachycardias associated with an SCN5A mutation

John Papagiannis et al. HeartRhythm Case Rep. .
No abstract available

Keywords: Atrial tachycardia; Catheter ablation; Quinidine; Sodium channel mutation; Ventricular tachycardia.

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Figures

Figure 1
Figure 1
A: Twelve-lead electrocardiogram of ectopic atrial tachycardia at presentation with narrow QRS (60 ms). B–D: Electroanatomic maps during atrial tachycardia showing earliest atrial activation in the right atrial appendage (B), superior vena cava–right atrium junction (C), and roof of left atrium (D). E: Intracardiac electrograms during one of the ablation attempts in the right atrial appendage.
Figure 2
Figure 2
Radiographic images, 12-lead electrocardiograms, and intracardiac electrograms during ventricular tachycardia showing various morphologies and ablation location attempts. A: Anterior right ventricle (RV) wall. B: RV apex. C: Left ventricular septum. D: Purkinje-like potentials preceding the QRS onset at a site in the anterior RV.
Figure 2
Figure 2
Radiographic images, 12-lead electrocardiograms, and intracardiac electrograms during ventricular tachycardia showing various morphologies and ablation location attempts. A: Anterior right ventricle (RV) wall. B: RV apex. C: Left ventricular septum. D: Purkinje-like potentials preceding the QRS onset at a site in the anterior RV.
Figure 3
Figure 3
A: Representative sodium currents recorded in Chinese hamster ovary (CHO) cells transfected with human cardiac wild-type SCN5A. B: Representative sodium currents recorded in CHO cells transfected with L939P. C: Summary of the current-voltage relationships of the activations of the 2 groups of sodium current. The voltage-clamp protocol is shown as an insert.
See this image and copyright information in PMC

References

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