Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 20;11(1):e0105321.
doi: 10.1128/mra.01053-21. Epub 2022 Jan 6.

BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients

Affiliations

BK Polyomavirus Subtypes II and IV in Hematopoietic Cell Transplant Recipients

Elizabeth A Odegard et al. Microbiol Resour Announc. .

Abstract

Symptomatic BK polyomavirus (BKPyV) infections are common and relevant in immunocompromised patients. Here, we present full-length BKPyV genomes from samples from patients who received hematopoietic cell transplants in the United States. These individuals had non-subtype I BKPyV, as determined by amplification, next-generation sequencing, and phylogenetic analysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
Representative BKPyV full genome sequences (downloaded from GenBank) were aligned, and phylogenetic inference was performed in BEAST version 1.10.4 (8). Sequences are labeled with their GenBank accession number, country of origin, and subtype, if known. Nodes separating subtypes are marked with closed circles and labeled. Sequences of interest (subject 1 and subject 2) are highlighted in red.

References

    1. Knowles WA. 2006. Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV), p 19–45. In Ahsan N (ed), Polyomaviruses and human diseases. Springer, New York, NY. - PubMed
    1. Gossai A, Waterboer T, Nelson HH, Michel A, Willhauck-Fleckenstein M, Farzan SF, Hoen AG, Christensen BC, Kelsey KT, Marsit CJ, Pawlita M, Karagas MR. 2016. Seroepidemiology of human polyomaviruses in a US population. Am J Epidemiol 183:61–69. doi:10.1093/aje/kwv155. - DOI - PMC - PubMed
    1. Blackard JT, Davies SM, Laskin BL. 2020. BK polyomavirus diversity: why viral variation matters. Rev Med Virol 30:e2102. doi:10.1002/rmv.2102. - DOI - PMC - PubMed
    1. Laskin BL, Denburg MR, Furth SL, Moatz T, Altrich M, Kleiboeker S, Lutzko C, Zhu X, Blackard JT, Jodele S, Lane A, Wallace G, Dandoy CE, Lake K, Duell A, Litts B, Seif AE, Olson T, Bunin N, Davies SM. 2020. The natural history of BK polyomavirus and the host immune response after stem cell transplantation. Clin Infect Dis 71:3044–3054. doi:10.1093/cid/ciz1194. - DOI - PMC - PubMed
    1. Odegard EA, Meeds HL, Kleiboeker SB, Ziady A, Sabulski A, Jodele S, Seif AE, Davies SM, Laskin BL, Blackard JT. 2022. Optimized amplification of BK polyomavirus in urine. J Virol Methods 299:114319. doi:10.1016/j.jviromet.2021.114319. - DOI - PMC - PubMed

LinkOut - more resources