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. 2022 Jan 1;23(13 Suppl 1 1S):e14-e24.
doi: 10.1097/PCC.0000000000002855.

Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding

Robert Russell  1 , David F Bauer  2 , Susan M Goobie  3   4 , Thorsten Haas  5 , Marianne E Nellis  6 , Daniel K Nishijima  7 , Adam M Vogel  8 , Jacques Lacroix  9 ; Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
Affiliations

Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding

Robert Russell et al. Pediatr Crit Care Med. .

Abstract

Objectives: To present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.

Design: Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children.

Setting: Not applicable.

Patients: Critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage.

Interventions: None.

Measurements and main results: A panel of eight experts developed expert-based statements for plasma and platelet transfusions in critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed one good practice statement and six expert consensus statements.

Conclusions: The lack of evidence precludes proposing recommendations on monitoring of the coagulation system and on plasma and platelets transfusion in critically ill pediatric patients with severe trauma, severe traumatic brain injury, or nontraumatic intracranial hemorrhage.

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Conflict of interest statement

Drs. Russell and Nellis received support for article research from the National Institutes of Health. Dr. Haas is a consultant for Octapharma. Dr. Nishijima is a consultant for Bristol Myers Squibb (BMS). Dr. Haas received funding from Octapharma. Dr. Nishijima received funding from BMS. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1:
Figure 1:. Papers flow chart for critically ill children with severe trauma
PRISMA diagram for studies on plasma and/or platelets in critically ill children with severe pediatric trauma.
Figure 2:
Figure 2:. Papers flow chart for critically ill children with TBI and ICH
PRISMA diagram for studies on plasma and/or platelets in critically ill children with traumatic brain injury and/or intracranial hemorrhage.
See this image and copyright information in PMC

References

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    1. The Joint Commission and the American Medical Association-Convened Physician Consortium. National Summit on Overuse. In: Physician Consortium for Performance Improvement® (PCPI®), editor. Proceedings from the National Summit on Overuse 2013. p. http://www.jointcommission.org/overuse_summit/
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