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Multicenter Study
. 2022 Oct;26(5):889-896.
doi: 10.1111/1744-9987.13790. Epub 2022 Jan 17.

The incidence of acute kidney injury and its association with mortality in patients diagnosed with COVID-19 followed up in intensive care unit

Nergiz Bayrakci  1 , Gülsüm Özkan  1 , Murat Şakaci  2 , Samet Sedef  3 , İlknur Erdem  4 , Nazan Tuna  4 , Levent Cem Mutlu  5 , İlker Yildirim  6 , Nuri Kiraz  7 , Berna Erdal  7 , Ebru Gelgeç  8 , Ayşen Erer  8 , Ömürhan Saraç  8 , Ahmet Yavuz  2 , Uysal Dolap  9 , Uluğ Bey Hayri  9 , İnci Kocadelioğlu  9 , Emrah Batmaz  9
Affiliations
Multicenter Study

The incidence of acute kidney injury and its association with mortality in patients diagnosed with COVID-19 followed up in intensive care unit

Nergiz Bayrakci et al. Ther Apher Dial. 2022 Oct.

Abstract

Introduction: The kidneys are some of the most frequently affected organs during coronavirus disease 2019 (COVID-19). This multicenter study evaluated the incidence of and risk factors for acute kidney injury (AKI) in COVID-19 patients followed up in intensive care unit (ICU) and its association with mortality.

Methods: Three hundred twenty-eight patients diagnosed with COVID-19 and hospitalized in ICU were included. Risk factors associated with AKI and mortality were evaluated.

Results: Eighty-eight patients (27.9%) were diagnosed with AKI. AKI was significantly associated with older age, higher baseline creatinine level, lower albumin level, and coexistence of cardiovascular disease and chronic obstructive pulmonary disease. Mortality in the entire study group was significantly associated with AKI, older age, requirement of invasive mechanical ventilation, higher neutrophil level, lower lymphocyte, and albumin levels.

Conclusion: AKI is frequently seen during the course of COVID-19 and is associated with high mortality. Identifying AKI-related risk factors appears essential in the management of COVID-19 patients.

Keywords: COVID-19; acute kidney injury; intensive care unit; mortality.

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References

REFERENCES

    1. Word Health Organization. WHO coronavirus (COVID-19) dashboard [Internet]. 2021. Available from: https://covid19.who.int/.
    1. Ahmadian E, Hosseiniyan Khatibi SM, Razi Soofiyani S, Abediazar S, Shoja MM, Ardalan M, et al. Covid-19 and kidney injury: pathophysiology and molecular mechanisms. Rev Med Virol. 2021;31(3):e2176.
    1. Ulusoy S, Ari D, Ozkan G, Cansiz M, Kaynar K. The frequency and outcome of acute kidney injury in a tertiary hospital: which factors affect mortality? Artif Organs. 2015;39(7):597-606.
    1. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):813-8.
    1. Hoste EAJ, Kellum JA, Selby NM, Zarbock A, Palevsky PM, Bagshaw SM, et al. Global epidemiology and outcomes of acute kidney injury. Nat Rev Nephrol. 2018;14(10):607-25.

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