Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity
- PMID: 34990577
- DOI: 10.1016/j.neuron.2021.12.013
Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity
Abstract
How is the exquisite cellular complexity of the vertebrate brain achieved? In this issue of Neuron, Closser et al. (2022) reveal that an expanded neuronal gene regulatory landscape may drive evolutionary cellular diversification by providing complex context and cell-specific control of effector genes.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity.Neuron. 2022 Jan 5;110(1):70-85.e6. doi: 10.1016/j.neuron.2021.10.014. Epub 2021 Nov 1. Neuron. 2022. PMID: 34727520 Free PMC article.
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