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Review
. 2022 Jan 6;15(1):8.
doi: 10.1186/s13041-021-00892-6.

Progress on the roles of MEF2C in neuropsychiatric diseases

Zhikun Zhang  1   2 , Yongxiang Zhao  3
Affiliations
Review

Progress on the roles of MEF2C in neuropsychiatric diseases

Zhikun Zhang et al. Mol Brain. .

Abstract

Myocyte Enhancer Factor 2 C (MEF2C), one of the transcription factors of the MADS-BOX family, is involved in embryonic brain development, neuronal formation and differentiation, as well as in the growth and pruning of axons and dendrites. MEF2C is also involved in the development of various neuropsychiatric disorders, such as autism spectrum disorders (ASD), epilepsy, schizophrenia and Alzheimer's disease (AD). Here, we review the relationship between MEF2C and neuropsychiatric disorders, and provide further insights into the mechanism of these diseases.

Keywords: MEF2C; Neurodevelopment; Neuropsychiatric disease; Synapse; Transcription factor.

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Conflict of interest statement

Both authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The functional regulation model of MEF2C in neuronal cells, where MEF2C is particularly important for the regulation of dendritic spines. The blue italics are MEF2C-associated psychoneurotic disorders
See this image and copyright information in PMC

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