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Comment
. 2022 Apr;19(4):453-455.
doi: 10.1038/s41423-021-00817-2. Epub 2022 Jan 7.

Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity

Elif Gelmez #  1 , Andreas Jeron #  1   2 , Dunja Bruder  3   4
Affiliations
Comment

Negative elongation factor: a key factor in the maintenance of intestinal epithelial barrier integrity

Elif Gelmez et al. Cell Mol Immunol. 2022 Apr.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Impact of epithelial NELF on transcriptional regulation of cell junction proteins in murine IEC. Epithelial NELF ensure sufficient expression of the cell junction proteins Cldn3, Cldn23 and Cgn. IEC-specific NELF-deficiency compromises the expression of Cldn3, Cldn23, and Cgn and promotes IEC necroptosis without obvious effects on intestinal barrier integrity. DSS-induced intestinal inflammation combined with IEC-specific NELF-deficiency, however, exacerbates intestinal inflammation by enhancing impairment of cell junction protein expression, IEC necroptosis, and consequently bacterial translocation from the intestinal lumen into the deeper gut tissue. Protein structures are symbolic. (Created with BioRender.com)
See this image and copyright information in PMC

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