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Comment
. 2022 May;19(5):558-560.
doi: 10.1038/s41423-021-00826-1. Epub 2022 Jan 7.

Spatiotemporal mapping of the leprosy granuloma landscape

Marco P La Manna  1   2 , Francesco Dieli  3   4 , Nadia Caccamo  1   2
Affiliations
Comment

Spatiotemporal mapping of the leprosy granuloma landscape

Marco P La Manna et al. Cell Mol Immunol. 2022 May.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Spatiotemporal architecture of granuloma in RR lesions, as defined by scRNA-seq and spatial sequencing. Shown is the positioning of the different cell types and their differentiation subsets in the context of RR granuloma, as derived by combined special and scRNA-seq. The gene signature of any cell type is indicated on the left. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • The cellular architecture of the antimicrobial response network in human leprosy granulomas.
    Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH 2nd, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. Ma F, et al. Nat Immunol. 2021 Jul;22(7):839-850. doi: 10.1038/s41590-021-00956-8. Epub 2021 Jun 24. Nat Immunol. 2021. PMID: 34168371 Free PMC article.

References

    1. Leprosy (Hansen’s disease). https://www.who.int/news-room/fact-sheets/detail/leprosy.
    1. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–73. - PubMed
    1. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science. 1991;254:277–9. doi: 10.1126/science.254.5029.277. - DOI - PubMed
    1. Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, et al. The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021;22:839–50. doi: 10.1038/s41590-021-00956-8. - DOI - PMC - PubMed
    1. Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, Morse M, et al. The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol. 2014;32:381–6. doi: 10.1038/nbt.2859. - DOI - PMC - PubMed

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