Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Feb;19(2):133-135.
doi: 10.1038/s41423-021-00831-4. Epub 2022 Jan 7.

Restoration of established systemic inflammation and autoimmunity by Foxp3+ regulatory T cells

Varun Kumar Sharma  1 , Jagadeesh Bayry  2
Affiliations
Comment

Restoration of established systemic inflammation and autoimmunity by Foxp3+ regulatory T cells

Varun Kumar Sharma et al. Cell Mol Immunol. 2022 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Foxp3-mediated Treg function in an established systemic inflammation and autoimmune condition.
A Foxp3LSLCd4creERT2L mice develop fatal severe inflammation and autoimmune responses affecting multiple organs early in life. Treatment of these young mice with 4-hydroxytamoxifen restores Foxp3 expression and, consequently, Treg cells that protect the mice from fatality. Compared to steady-state Treg cells, these Treg cells have higher expression of various genes associated with immunosuppression and are more potent suppressors of T cells. B Administration of diphtheria toxin to adult Foxp3DTR–GFP/LSLCd4creERT2 mice causes depletion of Treg cells, leading to massive immune activation, widespread autoimmune responses and fatality within two weeks. However, restoration of Foxp3 in Treg ‘wannabes’ in these mice by 4-hydroxytamoxifen injection protects the mice and ameliorates systemic inflammation. These Treg cells also exhibit enhanced proliferation, activation and immunosuppression-related protein expression. C Restored Thy-1.1−GFP+ Treg cells from Foxp3LSL/yCd4creERT2R26Tom mice exhibit the capacity for self-renewal and are maintained for a long period, possibly due to a unique subset of tissue-resident γREG+ Treg cells
See this image and copyright information in PMC

Comment on

References

    1. Sakaguchi S, Mikami N, Wing JB, Tanaka A, Ichiyama K, Ohkura N. Regulatory T cells and human disease. Annu Rev Immunol. 2020;38:541–66. doi: 10.1146/annurev-immunol-042718-041717. - DOI - PubMed
    1. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007;8:191–7. doi: 10.1038/ni1428. - DOI - PubMed
    1. Long SA, Buckner JH. CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game. J Immunol. 2011;187:2061–6. doi: 10.4049/jimmunol.1003224. - DOI - PMC - PubMed
    1. Sharma M, Das M, Stephen-Victor E, Galeotti C, Karnam A, Maddur MS, et al. Regulatory T cells induce activation rather than suppression of human basophils. Sci Immunol. 2018;3:eaan0829. doi: 10.1126/sciimmunol.aan0829. - DOI - PubMed
    1. Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β. J Exp Med. 2007;204:33–9. doi: 10.1084/jem.20061531. - DOI - PMC - PubMed

Substances