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Comparative Study
. 1987;65(3):353-6.

Single-dose kinetics of mefloquine in Brazilian male subjects

J M de Souza, P Heizmann, D E Schwartz
Comparative Study

Single-dose kinetics of mefloquine in Brazilian male subjects

J M de Souza et al. Bull World Health Organ. 1987.

Abstract

Ten male subjects from a region of the state of Pará, Brazil, where malaria is endemic received a single oral dose of 1000 mg mefloquine. The plasma levels of the drug and of its metabolite, 2,8-bis(trifluoromethyl)-4-quinolinecarboxylic acid, were determined densitometrically on thin-layer chromatography plates. The pharmacokinetic parameters obtained fell well within the range of values reported previously for Africans and Caucasians.

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References

    1. Bull World Health Organ. 1983;61(5):809-14 - PubMed
    1. Chemotherapy. 1982;28(1):70-84 - PubMed

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