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. 1987 Aug;5(4):163-7.

Effect of interleukin-2 on diabetes in the BB/Wor rat

D Burstein  1 , E S Handler, J Schindler, J Seals, J P Mordes, A A Rossini
Affiliations
  • PMID: 3499282

Effect of interleukin-2 on diabetes in the BB/Wor rat

D Burstein et al. Diabetes Res. 1987 Aug.

Abstract

Young diabetes prone BB/Wor rats were treated for 4-7 weeks with low dose (1,000 units/week) or high dose (75,000 units/week) recombinant human interleukin-2 (IL-2) and observed through 150 days of age for the development of spontaneous diabetes mellitus. Comparing treated rats with controls, it was found that IL-2 did not affect the cumulative incidence of diabetes, the age at onset of the disease, or peripheral lymphocyte subset numbers. High dose IL-2 administered to diabetes resistant BB/Wor rats also failed to induce the disease.

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