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Review
. 2021 Dec 15;12(1):533-544.
doi: 10.1515/tnsci-2020-0195. eCollection 2021 Jan 1.

Benefits of vitamin D supplementation to attenuate TBI secondary injury?

Kiana Saadatmand  1 , Saba Khan  1 , Quaratulain Hassan  1 , Raymond Hautamaki  1 , Rani Ashouri  1 , Josh Lua  1 , Sylvain Doré  1   2
Affiliations
Review

Benefits of vitamin D supplementation to attenuate TBI secondary injury?

Kiana Saadatmand et al. Transl Neurosci. .

Abstract

Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D's burgeoning role in improving patient outcomes, a new sector of research is focusing on the lesser-known implications of vitamin D on health. Traumatic brain injury (TBI) affects approximately 69 million people worldwide per year. Here, we summarize the current scientific understanding of vitamin D dynamics with TBI to elucidate a potential way to lessen the cascade of secondary damage after an initial insult, with the goal of improving overall patient outcomes. Because vitamin D supplementation has been correlated with better outcomes in other pathologies involving immune and inflammatory molecules, it is important to study the potential effect of vitamin D deficiency (VDD) and supplementation on TBI outcomes. Research on vitamin D supplementation in TBI remains in the preliminary stages. There is still much to learn about vitamin D deficiency, dosage, variants of supplementary forms, mechanisms, and its role in TBI.

Keywords: calcidiol; calcitriol; concussion; traumatic brain injury; vitamin D receptor.

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Conflict of interest statement

Conflict of interest: Sylvain Doré is a member of Translational Neuroscience’s Editorial Advisory Board. The other authors state no conflict of interest.

Figures

Figure 1
Figure 1
The synthesis of vitamin D.
See this image and copyright information in PMC

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