Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Nov 2;223(2):413-6.
doi: 10.1016/0014-5793(87)80330-7.

Inositol trisphosphate accumulation by high K+ stimulation in cultured adrenal chromaffin cells

N Sasakawa  1 , T Nakaki, S Yamamoto, R Kato
Affiliations
Free article

Inositol trisphosphate accumulation by high K+ stimulation in cultured adrenal chromaffin cells

N Sasakawa et al. FEBS Lett. .
Free article

Abstract

Stimulation with high K+ (KCl, 56 mM) of myo-[3H]inositol-prelabelled cells increased Ca2+ uptake and [3H]inositol trisphosphate (IP3) accumulation in a concentration-dependent manner. Nifedipine, a Ca2+ channel antagonist, inhibited high K+-induced [3H]IP3 accumulation and 45Ca2+ uptake with a similar potency. Furthermore, ionomycin (1 microM), a Ca2+ ionophore, also induced 45Ca2+ uptake and [3H]IP3 accumulation. These results indicate the existence of the Ca2+ uptake-triggered mechanism of IP3 formation in cultured adrenal chromaffin cells.

PubMed Disclaimer

Publication types

LinkOut - more resources