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. 1987 Sep;50(9):1153-5.
doi: 10.1136/jnnp.50.9.1153.

HLA and multiple sclerosis in south east Wales

R J Swingler  1 , P F Kirk, C Darke, D A Compston
Affiliations

HLA and multiple sclerosis in south east Wales

R J Swingler et al. J Neurol Neurosurg Psychiatry. 1987 Sep.

Abstract

A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.

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