CAR keys to unlock the intracellular immunopeptidome

Affiliations

Comment

Gabriel K Griffin. Sci Immunol. 2022.

. 2022 Jan 7;7(67):eabn9189.

doi: 10.1126/sciimmunol.abn9189. Epub 2022 Jan 7.

¹ Dana-Farber Cancer Institute, Boston, MA 02215, USA. Email: gabriel_griffin@dfci.harvard.edu.

Abstract

MHC-peptides derived from intracellular oncoproteins represent novel CAR-T targets in pediatric neuroblastoma.

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Yarmarkovich M, Marshall QF, Warrington JM, Premaratne R, Farrel A, Groff D, Li W, di Marco M, Runbeck E, Truong H, Toor JS, Tripathi S, Nguyen S, Shen H, Noel T, Church NL, Weiner A, Kendsersky N, Martinez D, Weisberg R, Christie M, Eisenlohr L, Bosse KR, Dimitrov DS, Stevanovic S, Sgourakis NG, Kiefel BR, Maris JM. Yarmarkovich M, et al. Nature. 2021 Nov;599(7885):477-484. doi: 10.1038/s41586-021-04061-6. Epub 2021 Nov 3. Nature. 2021. Retraction in: Nature. 2023 Nov;623(7988):872. doi: 10.1038/s41586-023-06731-z. PMID: 34732890 Free PMC article. Retracted.